TL;DR
Bill Falloon presents compelling recent advances in age reversal research, particularly focusing on young plasma therapies and OS (Yamanaka) transcription factors. Key 2024 breakthroughs include exosome-rich young plasma cutting epigenetic age in half in rats and OS factors doubling remaining lifespan in aged mice. These interventions are now moving to primate studies, with potential human applications on the horizon.
Key Recent Breakthroughs (2023-2024)
- Exosome-Rich Young Plasma Study (Feb 2024)
- Cut epigenetic age in half in old rats
- Reduced liver age by 74%, blood by 64%, heart by 46%, brain by 24%
- Required 4.8 trillion exosomes per treatment
- Improved multiple health markers including liver function, lipids, and glucose control
- OS (Yamanaka) Transcription Factors Study (2024)
- Doubled remaining lifespan in 77-year-old human equivalent mice
- Improved frailty scores and health markers
- Achieved results with only a fraction of intended dose
- Moving to primate studies
Current State of Age Reversal Research
- Young Plasma Research
- Extended median lifespan by ~7 human equivalent years
- Improved insulin sensitivity and immune function
- Reduced inflammation
- Currently advancing to dog and primate studies
- OS Transcription Factors Timeline
- 2006: Discovery that old cells can be reprogrammed
- 2011: Centenarian cells reprogrammed to embryonic stage
- 2022: Systemic aging reversal in mice
- 2024: Advancing to primate studies
Practical Applications & Testing
- Biological Age Testing Options
- DNA methylation testing (most accurate)
- Phenotypic age testing (9 standard blood markers)
- Regular blood testing recommended every 3-6 weeks
- Comprehensive panels available at RAADfest for $85-396
- Regulatory Challenges
- FDA blocking multi-interventional clinical trials
- Restrictions on promising treatments like thymosin alpha-1
- Need for better regulatory framework for aging interventions
Future Directions
- Moving from mouse studies to primate trials
- Developing multiple delivery methods (viral vectors, lipid nanoparticles)
- Combining multiple interventions (metformin, rapamycin, NAD restoration, etc.)
- Focus on translating successful animal studies to human applications
The presentation emphasizes we’re at a critical juncture where age reversal is transitioning from theoretical possibility to practical reality, with multiple promising interventions advancing rapidly through research phases.
Source:
YouTube Video — Bill Faloon on Age Reversal at RAADfest 2024 (Keynote Presentation).