Thymoquinone Inhibits Renal Cell Cancer Metastasis Through AMPK/mTOR-Mediated Autophagy
Key Findings Primary Discovery: Thymoquinone (TQ), extracted from Nigella sativa seeds, effectively inhibits renal cell carcinoma (RCC) metastasis by inducing autophagy through the AMPK/mTOR signaling pathway. Mechanism of Action: TQ activates AMPK phosphorylation while decreasing mTOR phosphorylation, leading to autophagy induction that subsequently inhibits cancer cell migration, invasion, and epithelial-mesenchymal transition (EMT). Experimental Results Cell […]
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