preventive medicine Archives

Grip Strength and Flexibility as Mortality Predictors: Meta-Analysis Reveals Dramatic Survival Advantages

TL;DR: A meta-analysis shows that both grip strength and whole-body flexibility are independently associated with reduced all-cause mortality risk. Higher flexibility scores were linked to significantly better survival rates in both men and women, even after adjusting for various health factors, though causation hasn’t been established. Key Statistical Findings Methodology Limitations The study suggests flexibility […]

aging research, epidemiology, flexibility, grip strength, healthspan, longevity, meta-analysis, mortality, physical fitness, preventive medicine, survival, VO2 max

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Nutrition

Long-Term Sardine Consumption and Gender-Equalized Longevity: 10-Year Results from a Portuguese Cohort Study

Summary of Key Findings This paper reports on a 20-year study examining whether regular sardine consumption affects longevity and reduces gender gaps in life expectancy. The study tracked 400 participants (200 Portuguese and 200 Portuguese-Canadians) who consumed sardines every other day for 10 years. Study Design and Participants Key Results After 10 Years Theoretical Background

aging research, cardiovascular protection, clinical trial, epidemiology, healthspan, longevity, metabolic health, mortality, omega-3 fatty acids, preventive medicine, sardines

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Research

Herpes Zoster Vaccine Reduces Dementia Risk by 20% in Welsh Natural Experiment

Study Design & Methodology Researchers used a unique natural experiment in Wales to study the causal effect of live-attenuated herpes zoster vaccination (Zostavax) on dementia. They exploited a sharp eligibility cutoff where: This created an abrupt change in vaccination rates (from 0.01% to 47.2%) between nearly identical populations, allowing researchers to bypass traditional confounding concerns

aging, aging research, clinical trial, dementia prevention, epidemiology, healthspan, herper-zoster, longevity, neurodegeneration, preventive medicine, vaccination

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Research

25-Year Japanese Study Identifies Optimal Diet and Lifestyle Factors for Cognitive Health and Functional Aging

A 25-year longitudinal study, the National Institute for Longevity Sciences – Longitudinal Study of Aging (NILS-LSA), reveals that specific dietary habits, lifestyle choices, and psychological factors significantly impact cognitive function and higher-level functional capacity in aging individuals. Notably, higher intake of certain fatty acids, soybeans, green tea, and dairy, coupled with dietary diversity, not smoking,

aging, aging biology, aging research, cognitive decline, dairy, dementia prevention, dietary diversity, green-tea, healthspan, longevity, MCFA, physical activity, preventive medicine, SCFA, soy

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Research

Spermidine Intake Reduces Mortality Risk by 24% in 20-Year Human Study: Dietary Polyamine Shows Anti-Aging Effects Equivalent to Being 5.7 Years Younger

Main Findings This prospective study provides the first evidence that higher dietary spermidine intake significantly reduces all-cause mortality in humans. The research demonstrates a strong dose-response relationship, with participants in the highest tertile of spermidine consumption showing mortality risks equivalent to being 5.7 years younger. Study Design and Population Primary Cohort: Bruneck Study Validation Cohort:

aging, anti-aging interventions, autophagy, calorie restriction, cancer prevention, cardiovascular protection, clinical trial, dietary intervention, epidemiology, healthspan, longevity, longevity research, metabolic health, mortality, preventive medicine, spermidine

Spermidine Intake Reduces Mortality Risk by 24% in 20-Year Human Study: Dietary Polyamine Shows Anti-Aging Effects Equivalent to Being 5.7 Years Younger Read Post »

Research

The Role of Flaxseed in Improving Human Health

1. Nutritional Profile and Key Components Flaxseed contains exceptionally high concentrations of bioactive compounds: Ground flaxseed provides superior bioavailability compared to whole seeds due to hard, impermeable seed coats that limit nutrient absorption. 2. Cardiovascular Benefits Cholesterol Management Significant lipid profile improvements across multiple studies: Meta-analysis of 14 studies confirmed effectiveness in both healthy individuals

anti-inflammatory, blood pressure management, cancer prevention, cardiovascular health, cholesterol management, diabetes prevention, flaxseed, gut health, lignans, menopause, mental health, nutritional supplementation, omega-3 fatty acids, preventive medicine, women's health

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Research

7-Year Clinical Trial Shows Synergistic Effects of Combined Telmisartan-Rosuvastatin Therapy in Preventing Dementia Among Elderly Hypertensive Patients, with Enhanced Benefits for APOE ε4 Carriers

TL;DR: A 7-year randomized clinical trial found that combining telmisartan (blood pressure medication) and rosuvastatin (cholesterol medication) significantly reduced dementia risk and cognitive decline in elderly hypertensive patients. The combination was particularly effective for patients carrying the APOE ε4 gene variant, which is associated with increased dementia risk. Key Findings: This study provides strong evidence