neuroprotection

Research

Berberine Extends Healthspan and Delays Neurodegeneration via ROS-PMK-1/SKN-1 Pathway

Key Findings Lifespan Extension: Berberine significantly extended lifespan in C. elegans at concentrations of 1μM (19% increase), 10μM (28% increase), and 100μM (18% increase), with 10μM showing optimal effects. Healthspan Improvements: At 10μM, berberine reduced age pigments (lipofuscin accumulation), increased locomotory ability (body bends per minute), and maintained fertility unchanged compared to controls. Molecular Mechanism […]

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Nutrition

Maximizing Coffee’s Health Benefits for Longevity

This video provides a comprehensive guide on how to maximize the health and longevity benefits of coffee while minimizing potential negative side effects. Key Takeaways 1. Longevity and Cardiovascular Health 2. Optimal Timing for Consumption 3. Metabolic and Cancer Risk Reduction 4. Gut Health Benefits 5. Brewing Method and Bean Selection 6. Caffeine vs. Decaf

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Research

SGLTi as a Geroprotective Agent: Comprehensive Review of Clinical Benefits and Mechanisms

TL;DR: SGLTi, originally developed for type 2 diabetes, shows promise as a geroprotective agent that may slow aging, prevent age-related diseases, and improve life expectancy. Its mechanisms of action include promoting autophagy, restoring mitochondrial health, reducing oxidative stress, and decreasing inflammation. Large clinical studies demonstrate reduced risks for many common age-related conditions and improved overall

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SGLTi as a Geroprotective Agent: Comprehensive Review of Clinical Benefits and Mechanisms Read Post »

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