TL;DR: A 2024 Nature study shows that inhibiting interleukin-11 (IL-11) extends median mouse lifespan by 28.7% when administered at an age equivalent to human late-50s, with improved health markers and reduced tumor incidence. This extension rivals that seen with rapamycin, raising questions about whether IL-11 inhibition works through similar or complementary mechanisms. Key Findings Lifespan […]
TL;DR: A large-scale mouse study (n=960) found that both fasting and calorie restriction (CR) extended lifespan, with 40% CR showing the most dramatic results (36% increase in median lifespan). The 40% CR group also maintained youthful physical activity levels throughout life. Key biomarkers like lymphocyte count and red blood cell distribution width (RDW) strongly predicted
TL;DR: Pig-derived exosomes (E5) significantly extended lifespan and improved health markers in female Sprague-Dawley rats, with one treated rat setting a world longevity record for its species at just over 4 years. Key Findings:
TL;DR Bill Falloon presents compelling recent advances in age reversal research, particularly focusing on young plasma therapies and OS (Yamanaka) transcription factors. Key 2024 breakthroughs include exosome-rich young plasma cutting epigenetic age in half in rats and OS factors doubling remaining lifespan in aged mice. These interventions are now moving to primate studies, with potential