lifespan extension Archives

Genistein Extends Mouse Lifespan 10% Through Gut Microbiome Modulation – Soy Compound Shows Promise for Human Longevity

Key Findings A 2023 study from China Agricultural University demonstrated that dietary genistein supplementation significantly extends both healthspan and lifespan in mice through gut microbiome modifications. Longevity Benefits Mechanism of Action Gut Microbiome Changes: Fecal Transplant Validation: Study Design Genistein Sources and Background Genistein is found in leguminous plants, particularly soybeans and coffee beans. Previous […]

aging, aging research, animal model, anti-aging interventions, genistein, gut microbiome, healthspan, inflammation, lifespan extension, longevity, longevity research, metabolic health, mouse study, preclinical study, SCFA, translational medicine

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Research

Berberine Extends Healthspan and Delays Neurodegeneration via ROS-PMK-1/SKN-1 Pathway

Key Findings Lifespan Extension: Berberine significantly extended lifespan in C. elegans at concentrations of 1μM (19% increase), 10μM (28% increase), and 100μM (18% increase), with 10μM showing optimal effects. Healthspan Improvements: At 10μM, berberine reduced age pigments (lipofuscin accumulation), increased locomotory ability (body bends per minute), and maintained fertility unchanged compared to controls. Molecular Mechanism

aging research, animal model, anti aging interventions, berberine, biomedical research, healthspan, lifespan extension, longevity research, neuroprotection, oxidative stress, preclinical study, supplements

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Research

SGLTi as a Geroprotective Agent: Comprehensive Review of Clinical Benefits and Mechanisms

TL;DR: SGLTi, originally developed for type 2 diabetes, shows promise as a geroprotective agent that may slow aging, prevent age-related diseases, and improve life expectancy. Its mechanisms of action include promoting autophagy, restoring mitochondrial health, reducing oxidative stress, and decreasing inflammation. Large clinical studies demonstrate reduced risks for many common age-related conditions and improved overall

aging research, autophagy, cancer prevention, cardiovascular protection, clinical trials, diabetes treatment, drug repurposing, healthspan, inflammation, lifespan extension, longevity medicine, mitochondrial health, neuroprotection, oxidative stress, renal protection, SGLTi

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Research

IL-11 Inhibition Extends Mouse Lifespan by 29%: A Breakthrough Rivaling Rapamycin’s Effects

TL;DR: A 2024 Nature study shows that inhibiting interleukin-11 (IL-11) extends median mouse lifespan by 28.7% when administered at an age equivalent to human late-50s, with improved health markers and reduced tumor incidence. This extension rivals that seen with rapamycin, raising questions about whether IL-11 inhibition works through similar or complementary mechanisms. Key Findings Lifespan

aging biology, anti aging therapy, biomedical research, cell senescence, IL-11, interleukin 11, lifespan extension, longevity research, metabolic health, mouse study, Nature publication, protein signaling, rapamycin, tumor reduction

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Research

Fasting and Calorie Restriction Effects on Lifespan: Insights from a 960-Mouse Study with Human Biomarker Validation

TL;DR: A large-scale mouse study (n=960) found that both fasting and calorie restriction (CR) extended lifespan, with 40% CR showing the most dramatic results (36% increase in median lifespan). The 40% CR group also maintained youthful physical activity levels throughout life. Key biomarkers like lymphocyte count and red blood cell distribution width (RDW) strongly predicted

aging biomarkers, calorie restriction, intermittent fasting, lifespan extension, longevity, longevity research, lymphocytes, metabolic health, mouse study, physical activity, RDW

Fasting and Calorie Restriction Effects on Lifespan: Insights from a 960-Mouse Study with Human Biomarker Validation Read Post »