inflammation Archives - TLDR Longevity

Genistein Extends Mouse Lifespan 10% Through Gut Microbiome Modulation – Soy Compound Shows Promise for Human Longevity

Key Findings A 2023 study from China Agricultural University demonstrated that dietary genistein supplementation significantly extends both healthspan and lifespan in mice through gut microbiome modifications. Longevity Benefits Mechanism of Action Gut Microbiome Changes: Fecal Transplant Validation: Study Design Genistein Sources and Background Genistein is found in leguminous plants, particularly soybeans and coffee beans. Previous […]

aging, aging research, animal model, anti-aging interventions, genistein, gut microbiome, healthspan, inflammation, lifespan extension, longevity, longevity research, metabolic health, mouse study, preclinical study, SCFA, translational medicine

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Research

Thymoquinone Inhibits Renal Cell Cancer Metastasis Through AMPK/mTOR-Mediated Autophagy

Key Findings Primary Discovery: Thymoquinone (TQ), extracted from Nigella sativa seeds, effectively inhibits renal cell carcinoma (RCC) metastasis by inducing autophagy through the AMPK/mTOR signaling pathway. Mechanism of Action: TQ activates AMPK phosphorylation while decreasing mTOR phosphorylation, leading to autophagy induction that subsequently inhibits cancer cell migration, invasion, and epithelial-mesenchymal transition (EMT). Experimental Results Cell

anti-aging therapy, autophagy, biomedical research, black-cumin-seed, cancer prevention, drug repurposing, inflammation, oxidative stress, renal protection, research, science, thymoquinone

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Research

SGLTi as a Geroprotective Agent: Comprehensive Review of Clinical Benefits and Mechanisms

TL;DR: SGLTi, originally developed for type 2 diabetes, shows promise as a geroprotective agent that may slow aging, prevent age-related diseases, and improve life expectancy. Its mechanisms of action include promoting autophagy, restoring mitochondrial health, reducing oxidative stress, and decreasing inflammation. Large clinical studies demonstrate reduced risks for many common age-related conditions and improved overall

aging research, autophagy, cancer prevention, cardiovascular protection, clinical trials, diabetes treatment, drug repurposing, healthspan, inflammation, lifespan extension, longevity medicine, mitochondrial health, neuroprotection, oxidative stress, renal protection, SGLTi

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