cognitive decline Archives

25-Year Japanese Study Identifies Optimal Diet and Lifestyle Factors for Cognitive Health and Functional Aging

A 25-year longitudinal study, the National Institute for Longevity Sciences – Longitudinal Study of Aging (NILS-LSA), reveals that specific dietary habits, lifestyle choices, and psychological factors significantly impact cognitive function and higher-level functional capacity in aging individuals. Notably, higher intake of certain fatty acids, soybeans, green tea, and dairy, coupled with dietary diversity, not smoking, […]

aging, aging biology, aging research, cognitive decline, dairy, dementia prevention, dietary diversity, green-tea, healthspan, longevity, MCFA, physical activity, preventive medicine, SCFA, soy

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Research

17α-Estradiol Preferentially Protects APOE4 Male Mice Against Aging

Main Finding The longevity drug 17α-estradiol (17αE2) provides greater protection against aging-related decline in male mice carrying the APOE4 gene variant compared to APOE3 mice. APOE4 is associated with shorter lifespan and higher Alzheimer’s disease risk, but 17αE2 treatment largely reverses these negative effects. Key Results Aging Markers Metabolic Improvements Brain Function Molecular Changes Study

aging biomarkers, aging research, animal model, anti aging therapy, anti-aging interventions, APOE e4, biomedical research, cognitive decline, DNA methylation, epigenetic aging, longevity, metabolic health, personalized medicine, preclinical study

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Research

7-Year Clinical Trial Shows Synergistic Effects of Combined Telmisartan-Rosuvastatin Therapy in Preventing Dementia Among Elderly Hypertensive Patients, with Enhanced Benefits for APOE ε4 Carriers

TL;DR: A 7-year randomized clinical trial found that combining telmisartan (blood pressure medication) and rosuvastatin (cholesterol medication) significantly reduced dementia risk and cognitive decline in elderly hypertensive patients. The combination was particularly effective for patients carrying the APOE ε4 gene variant, which is associated with increased dementia risk. Key Findings: This study provides strong evidence

APOE e4, blood pressure management, cardiovascular medicine, cholesterol management, clinical trial, cognitive decline, combination therapy, dementia prevention, genetic factors, geriatric medicine, hypertension treatment, personalized medicine, preventive medicine, rosuvastatin, telmisartan

7-Year Clinical Trial Shows Synergistic Effects of Combined Telmisartan-Rosuvastatin Therapy in Preventing Dementia Among Elderly Hypertensive Patients, with Enhanced Benefits for APOE ε4 Carriers Read Post »