cancer prevention Archives

Thymoquinone Inhibits Renal Cell Cancer Metastasis Through AMPK/mTOR-Mediated Autophagy

Key Findings Primary Discovery: Thymoquinone (TQ), extracted from Nigella sativa seeds, effectively inhibits renal cell carcinoma (RCC) metastasis by inducing autophagy through the AMPK/mTOR signaling pathway. Mechanism of Action: TQ activates AMPK phosphorylation while decreasing mTOR phosphorylation, leading to autophagy induction that subsequently inhibits cancer cell migration, invasion, and epithelial-mesenchymal transition (EMT). Experimental Results Cell […]

anti-aging therapy, autophagy, biomedical research, black-cumin-seed, cancer prevention, drug repurposing, inflammation, oxidative stress, renal protection, research, science, thymoquinone

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Research

Spermidine Intake Reduces Mortality Risk by 24% in 20-Year Human Study: Dietary Polyamine Shows Anti-Aging Effects Equivalent to Being 5.7 Years Younger

Main Findings This prospective study provides the first evidence that higher dietary spermidine intake significantly reduces all-cause mortality in humans. The research demonstrates a strong dose-response relationship, with participants in the highest tertile of spermidine consumption showing mortality risks equivalent to being 5.7 years younger. Study Design and Population Primary Cohort: Bruneck Study Validation Cohort:

aging, anti-aging interventions, autophagy, calorie restriction, cancer prevention, cardiovascular protection, clinical trial, dietary intervention, epidemiology, healthspan, longevity, longevity research, metabolic health, mortality, preventive medicine, spermidine

Spermidine Intake Reduces Mortality Risk by 24% in 20-Year Human Study: Dietary Polyamine Shows Anti-Aging Effects Equivalent to Being 5.7 Years Younger Read Post »

Nutrition

Maximizing Coffee’s Health Benefits for Longevity

This video provides a comprehensive guide on how to maximize the health and longevity benefits of coffee while minimizing potential negative side effects. Key Takeaways 1. Longevity and Cardiovascular Health 2. Optimal Timing for Consumption 3. Metabolic and Cancer Risk Reduction 4. Gut Health Benefits 5. Brewing Method and Bean Selection 6. Caffeine vs. Decaf

anti-aging interventions, antioxidants, biohacking, cancer prevention, cardiovascular protection, circadian rhythm, coffee science, epigenetic aging, gut microbiome, healthspan, longevity, longevity research, metabolic health, neuroprotection

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Research

The Role of Flaxseed in Improving Human Health

1. Nutritional Profile and Key Components Flaxseed contains exceptionally high concentrations of bioactive compounds: Ground flaxseed provides superior bioavailability compared to whole seeds due to hard, impermeable seed coats that limit nutrient absorption. 2. Cardiovascular Benefits Cholesterol Management Significant lipid profile improvements across multiple studies: Meta-analysis of 14 studies confirmed effectiveness in both healthy individuals

anti-inflammatory, blood pressure management, cancer prevention, cardiovascular health, cholesterol management, diabetes prevention, flaxseed, gut health, lignans, menopause, mental health, nutritional supplementation, omega-3 fatty acids, preventive medicine, women's health

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Research

SGLTi as a Geroprotective Agent: Comprehensive Review of Clinical Benefits and Mechanisms

TL;DR: SGLTi, originally developed for type 2 diabetes, shows promise as a geroprotective agent that may slow aging, prevent age-related diseases, and improve life expectancy. Its mechanisms of action include promoting autophagy, restoring mitochondrial health, reducing oxidative stress, and decreasing inflammation. Large clinical studies demonstrate reduced risks for many common age-related conditions and improved overall

aging research, autophagy, cancer prevention, cardiovascular protection, clinical trials, diabetes treatment, drug repurposing, healthspan, inflammation, lifespan extension, longevity medicine, mitochondrial health, neuroprotection, oxidative stress, renal protection, SGLTi

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