Berberine Extends Healthspan and Delays Neurodegeneration via ROS-PMK-1/SKN-1 Pathway
Key Findings Lifespan Extension: Berberine significantly extended lifespan in C. elegans at concentrations of 1μM (19% increase), 10μM (28% increase), and 100μM (18% increase), with 10μM showing optimal effects. Healthspan Improvements: At 10μM, berberine reduced age pigments (lipofuscin accumulation), increased locomotory ability (body bends per minute), and maintained fertility unchanged compared to controls. Molecular Mechanism […]
Berberine Extends Healthspan and Delays Neurodegeneration via ROS-PMK-1/SKN-1 Pathway Read Post »