anti-aging interventions Archives

Genistein Extends Mouse Lifespan 10% Through Gut Microbiome Modulation – Soy Compound Shows Promise for Human Longevity

Key Findings A 2023 study from China Agricultural University demonstrated that dietary genistein supplementation significantly extends both healthspan and lifespan in mice through gut microbiome modifications. Longevity Benefits Mechanism of Action Gut Microbiome Changes: Fecal Transplant Validation: Study Design Genistein Sources and Background Genistein is found in leguminous plants, particularly soybeans and coffee beans. Previous […]

aging, aging research, animal model, anti-aging interventions, genistein, gut microbiome, healthspan, inflammation, lifespan extension, longevity, longevity research, metabolic health, mouse study, preclinical study, SCFA, translational medicine

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Research

Spermidine Intake Reduces Mortality Risk by 24% in 20-Year Human Study: Dietary Polyamine Shows Anti-Aging Effects Equivalent to Being 5.7 Years Younger

Main Findings This prospective study provides the first evidence that higher dietary spermidine intake significantly reduces all-cause mortality in humans. The research demonstrates a strong dose-response relationship, with participants in the highest tertile of spermidine consumption showing mortality risks equivalent to being 5.7 years younger. Study Design and Population Primary Cohort: Bruneck Study Validation Cohort:

aging, anti-aging interventions, autophagy, calorie restriction, cancer prevention, cardiovascular protection, clinical trial, dietary intervention, epidemiology, healthspan, longevity, longevity research, metabolic health, mortality, preventive medicine, spermidine

Spermidine Intake Reduces Mortality Risk by 24% in 20-Year Human Study: Dietary Polyamine Shows Anti-Aging Effects Equivalent to Being 5.7 Years Younger Read Post »

Nutrition

Maximizing Coffee’s Health Benefits for Longevity

This video provides a comprehensive guide on how to maximize the health and longevity benefits of coffee while minimizing potential negative side effects. Key Takeaways 1. Longevity and Cardiovascular Health 2. Optimal Timing for Consumption 3. Metabolic and Cancer Risk Reduction 4. Gut Health Benefits 5. Brewing Method and Bean Selection 6. Caffeine vs. Decaf

anti-aging interventions, antioxidants, biohacking, cancer prevention, cardiovascular protection, circadian rhythm, coffee science, epigenetic aging, gut microbiome, healthspan, longevity, longevity research, metabolic health, neuroprotection

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Research

17α-Estradiol Preferentially Protects APOE4 Male Mice Against Aging

Main Finding The longevity drug 17α-estradiol (17αE2) provides greater protection against aging-related decline in male mice carrying the APOE4 gene variant compared to APOE3 mice. APOE4 is associated with shorter lifespan and higher Alzheimer’s disease risk, but 17αE2 treatment largely reverses these negative effects. Key Results Aging Markers Metabolic Improvements Brain Function Molecular Changes Study

aging biomarkers, aging research, animal model, anti aging therapy, anti-aging interventions, APOE e4, biomedical research, cognitive decline, DNA methylation, epigenetic aging, longevity, metabolic health, personalized medicine, preclinical study

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Research

The 2024 Longevity Breakthrough: From Mouse Models to Human Potential – A Comprehensive Review of Bill Falloon’s RAADfest Presentation

TL;DR Bill Falloon presents compelling recent advances in age reversal research, particularly focusing on young plasma therapies and OS (Yamanaka) transcription factors. Key 2024 breakthroughs include exosome-rich young plasma cutting epigenetic age in half in rats and OS factors doubling remaining lifespan in aged mice. These interventions are now moving to primate studies, with potential

aging biomarkers, anti-aging interventions, clinical trials, DNA methylation, epigenetic aging, exosome therapy, life extension, longevity research, regenerative medicine, research, science, Yamanaka factors, young plasma

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