animal model

Nutrition

Genistein Extends Mouse Lifespan 10% Through Gut Microbiome Modulation – Soy Compound Shows Promise for Human Longevity

Key Findings A 2023 study from China Agricultural University demonstrated that dietary genistein supplementation significantly extends both healthspan and lifespan in mice through gut microbiome modifications. Longevity Benefits Mechanism of Action Gut Microbiome Changes: Fecal Transplant Validation: Study Design Genistein Sources and Background Genistein is found in leguminous plants, particularly soybeans and coffee beans. Previous […]

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Research

Berberine Extends Healthspan and Delays Neurodegeneration via ROS-PMK-1/SKN-1 Pathway

Key Findings Lifespan Extension: Berberine significantly extended lifespan in C. elegans at concentrations of 1μM (19% increase), 10μM (28% increase), and 100μM (18% increase), with 10μM showing optimal effects. Healthspan Improvements: At 10μM, berberine reduced age pigments (lipofuscin accumulation), increased locomotory ability (body bends per minute), and maintained fertility unchanged compared to controls. Molecular Mechanism

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Berberine Extends Healthspan and Delays Neurodegeneration via ROS-PMK-1/SKN-1 Pathway Read Post »

Research

17α-Estradiol Preferentially Protects APOE4 Male Mice Against Aging

Main Finding The longevity drug 17α-estradiol (17αE2) provides greater protection against aging-related decline in male mice carrying the APOE4 gene variant compared to APOE3 mice. APOE4 is associated with shorter lifespan and higher Alzheimer’s disease risk, but 17αE2 treatment largely reverses these negative effects. Key Results Aging Markers Metabolic Improvements Brain Function Molecular Changes Study

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Research

Record-Breaking Lifespan Extension in Aged Rats Using Pig-Derived Exosomes: A Preclinical Study

TL;DR: Pig-derived exosomes (E5) significantly extended lifespan and improved health markers in female Sprague-Dawley rats, with one treated rat setting a world longevity record for its species at just over 4 years. Key Findings:

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