aging research

SGLTi as a Geroprotective Agent: Comprehensive Review of Clinical Benefits and Mechanisms

TL;DR: SGLTi, originally developed for type 2 diabetes, shows promise as a geroprotective agent that may slow aging, prevent age-related diseases, and improve life expectancy. Its mechanisms of action include promoting autophagy, restoring mitochondrial health, reducing oxidative stress, and decreasing inflammation. Large clinical studies demonstrate reduced risks for many common age-related conditions and improved overall […]

aging research, autophagy, cancer prevention, cardiovascular protection, clinical trials, diabetes treatment, drug repurposing, healthspan, inflammation, lifespan extension, longevity medicine, mitochondrial health, neuroprotection, oxidative stress, renal protection, SGLTi

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Fitness

Higher Whole-Body Flexibility Associated with 60-85% Lower Mortality Risk: New Evidence from Flex Index Study

TL;DR: A meta-analysis shows that both grip strength and whole-body flexibility are independently associated with reduced all-cause mortality risk. Higher flexibility scores were linked to significantly better survival rates in both men and women, even after adjusting for various health factors, though causation hasn’t been established. Key Statistical Findings Methodology Limitations The study suggests flexibility

aging, aging research, biohacking, biomechanics, epidemiology, exercise science, fitness, fitness science, flex index, flexibility, grip strength, healthspan, longevity, meta-analysis, mobility, mortality, physical fitness, preventive medicine, strength training, survival, VO2 max

Higher Whole-Body Flexibility Associated with 60-85% Lower Mortality Risk: New Evidence from Flex Index Study Read Post »