TLDR Longevity -

SGLTi as a Geroprotective Agent: Comprehensive Review of Clinical Benefits and Mechanisms

TL;DR: SGLTi, originally developed for type 2 diabetes, shows promise as a geroprotective agent that may slow aging, prevent age-related diseases, and improve life expectancy. Its mechanisms of action include promoting autophagy, restoring mitochondrial health, reducing oxidative stress, and decreasing inflammation. Large clinical studies demonstrate reduced risks for many common age-related conditions and improved overall […]

aging research, autophagy, cancer prevention, cardiovascular protection, clinical trials, diabetes treatment, drug repurposing, healthspan, inflammation, lifespan extension, longevity medicine, mitochondrial health, neuroprotection, oxidative stress, renal protection, SGLTi

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Research

IL-11 Inhibition Extends Mouse Lifespan by 29%: A Breakthrough Rivaling Rapamycin’s Effects

TL;DR: A 2024 Nature study shows that inhibiting interleukin-11 (IL-11) extends median mouse lifespan by 28.7% when administered at an age equivalent to human late-50s, with improved health markers and reduced tumor incidence. This extension rivals that seen with rapamycin, raising questions about whether IL-11 inhibition works through similar or complementary mechanisms. Key Findings Lifespan

aging biology, anti aging therapy, biomedical research, cell senescence, IL-11, interleukin 11, lifespan extension, longevity research, metabolic health, mouse study, Nature publication, protein signaling, rapamycin, tumor reduction

IL-11 Inhibition Extends Mouse Lifespan by 29%: A Breakthrough Rivaling Rapamycin’s Effects Read Post »

Research

7-Year Clinical Trial Shows Synergistic Effects of Combined Telmisartan-Rosuvastatin Therapy in Preventing Dementia Among Elderly Hypertensive Patients, with Enhanced Benefits for APOE ε4 Carriers

TL;DR: A 7-year randomized clinical trial found that combining telmisartan (blood pressure medication) and rosuvastatin (cholesterol medication) significantly reduced dementia risk and cognitive decline in elderly hypertensive patients. The combination was particularly effective for patients carrying the APOE ε4 gene variant, which is associated with increased dementia risk. Key Findings: This study provides strong evidence

APOE e4, blood pressure management, cardiovascular medicine, cholesterol management, clinical trial, cognitive decline, combination therapy, dementia prevention, genetic factors, geriatric medicine, hypertension treatment, personalized medicine, preventive medicine, rosuvastatin, telmisartan

7-Year Clinical Trial Shows Synergistic Effects of Combined Telmisartan-Rosuvastatin Therapy in Preventing Dementia Among Elderly Hypertensive Patients, with Enhanced Benefits for APOE ε4 Carriers Read Post »

Research

Fasting and Calorie Restriction Effects on Lifespan: Insights from a 960-Mouse Study with Human Biomarker Validation

TL;DR: A large-scale mouse study (n=960) found that both fasting and calorie restriction (CR) extended lifespan, with 40% CR showing the most dramatic results (36% increase in median lifespan). The 40% CR group also maintained youthful physical activity levels throughout life. Key biomarkers like lymphocyte count and red blood cell distribution width (RDW) strongly predicted

aging biomarkers, calorie restriction, intermittent fasting, lifespan extension, longevity, longevity research, lymphocytes, metabolic health, mouse study, physical activity, RDW

Fasting and Calorie Restriction Effects on Lifespan: Insights from a 960-Mouse Study with Human Biomarker Validation Read Post »

Research

Record-Breaking Lifespan Extension in Aged Rats Using Pig-Derived Exosomes: A Preclinical Study

TL;DR: Pig-derived exosomes (E5) significantly extended lifespan and improved health markers in female Sprague-Dawley rats, with one treated rat setting a world longevity record for its species at just over 4 years. Key Findings:

aging biomarkers, animal model, anti aging, exosomes, extracellular vesicles, geriatric medicine, healthspan, life extension, longevity research, preclinical study, regenerative medicine, rejuvenation therapy, Sprague-Dawley rats, translational medicine

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Research

The 2024 Longevity Breakthrough: From Mouse Models to Human Potential – A Comprehensive Review of Bill Falloon’s RAADfest Presentation

TL;DR Bill Falloon presents compelling recent advances in age reversal research, particularly focusing on young plasma therapies and OS (Yamanaka) transcription factors. Key 2024 breakthroughs include exosome-rich young plasma cutting epigenetic age in half in rats and OS factors doubling remaining lifespan in aged mice. These interventions are now moving to primate studies, with potential

aging biomarkers, anti-aging interventions, clinical trials, DNA methylation, epigenetic aging, exosome therapy, life extension, longevity research, regenerative medicine, research, science, Yamanaka factors, young plasma

The 2024 Longevity Breakthrough: From Mouse Models to Human Potential – A Comprehensive Review of Bill Falloon’s RAADfest Presentation Read Post »

Fitness

Higher Whole-Body Flexibility Associated with 60-85% Lower Mortality Risk: New Evidence from Flex Index Study

TL;DR: A meta-analysis shows that both grip strength and whole-body flexibility are independently associated with reduced all-cause mortality risk. Higher flexibility scores were linked to significantly better survival rates in both men and women, even after adjusting for various health factors, though causation hasn’t been established. Key Statistical Findings Methodology Limitations The study suggests flexibility

aging, aging research, biohacking, biomechanics, epidemiology, exercise science, fitness, fitness science, flex index, flexibility, grip strength, healthspan, longevity, meta-analysis, mobility, mortality, physical fitness, preventive medicine, strength training, survival, VO2 max

Higher Whole-Body Flexibility Associated with 60-85% Lower Mortality Risk: New Evidence from Flex Index Study Read Post »